Mitigating arrhythmia risk in Hydroxychloroquine and Azithromycin treated COVID-19 patients using arrhythmia risk management plan.
Identifieur interne : 000337 ( Main/Exploration ); précédent : 000336; suivant : 000338Mitigating arrhythmia risk in Hydroxychloroquine and Azithromycin treated COVID-19 patients using arrhythmia risk management plan.
Auteurs : Kazimieras Maneikis [Lituanie] ; Ugne Ringeleviciute [Lituanie] ; Justinas Bacevicius [Lituanie] ; Egle Dieninyte-Misiune [Lituanie] ; Emilija Burokaite [Lituanie] ; Gintare Kazbaraite [Lituanie] ; Marta Monika Janusaite [Lituanie] ; Austeja Dapkeviciute [Lituanie] ; Andrius Zucenka [Lituanie] ; Valdas Peceliunas [Lituanie] ; Lina Kryzauskaite [Lituanie] ; Vytautas Kasiulevicius [Lituanie] ; Donata Ringaitiene [Lituanie] ; Birute Zablockiene [Lituanie] ; Tadas Zvirblis [Lituanie] ; Germanas Marinskis [Lituanie] ; Ligita Jancoriene [Lituanie] ; Laimonas Griskevicius [Lituanie]Source :
- International journal of cardiology. Heart & vasculature [ 2352-9067 ] ; 2021.
Abstract
Aims
To assess cardiac safety in COVID-19 patients treated with the combination of Hydroxychloroquine and Azithromycin using arrhythmia risk management plan.
Methods and results
We retrospectively examined arrhythmia safety of treatment with Hydroxychloroquine and Azithromycin in the setting of pre-defined arrhythmia risk management plan. The data was analyzed using R statistical package version 4.0.0. A two-tailed p-value<0.05 was considered significant. 81 patients were included from March 23rd to May 10th 2020. The median age was 59 years, 58.0% were female. The majority of the study population (82.7%) had comorbidities, 98.8% had radiological signs of pneumonia. Fourteen patients (17.3%) experienced QTc ≥ 480 ms and 16 patients (19.8%) had an increase of QTc ≥ 60 ms. Seven patients (8.6%) had QTc prolongation of ≥ 500 ms. The treatment was discontinued in 4 patients (4.9%). None of the patients developed ventricular tachycardia. The risk factors significantly associated with QTc ≥ 500 ms were hypokalemia (p = 0.032) and use of diuretics during the treatment (p = 0.020). Three patients (3.7%) died, the cause of death was bacterial superinfection with septic shock in two patients, and disseminated intravascular coagulation with multiple organ failure in one patient. None of these deaths were associated with cardiac arrhythmias.
Conclusion
We recorded a low incidence of QTc prolongation ≥ 500 ms and no ventricular tachycardia events in COVID-19 patients treated with Hydroxychloroquine and Azithromycin using cardiac arrhythmia risk management plan.
DOI: 10.1016/j.ijcha.2020.100685
PubMed: 33335973
PubMed Central: PMC7734220
Affiliations:
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Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Kryzauskaite, Lina" sort="Kryzauskaite, Lina" uniqKey="Kryzauskaite L" first="Lina" last="Kryzauskaite">Lina Kryzauskaite</name><affiliation wicri:level="1"><nlm:affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Kasiulevicius, Vytautas" sort="Kasiulevicius, Vytautas" uniqKey="Kasiulevicius V" first="Vytautas" last="Kasiulevicius">Vytautas Kasiulevicius</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Ringaitiene, Donata" sort="Ringaitiene, Donata" uniqKey="Ringaitiene D" first="Donata" last="Ringaitiene">Donata Ringaitiene</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Anesthesiology, Intensive Care and Pain Management Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Anesthesiology, Intensive Care and Pain Management Centre, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Zablockiene, Birute" sort="Zablockiene, Birute" uniqKey="Zablockiene B" first="Birute" last="Zablockiene">Birute Zablockiene</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Zvirblis, Tadas" sort="Zvirblis, Tadas" uniqKey="Zvirblis T" first="Tadas" last="Zvirblis">Tadas Zvirblis</name><affiliation wicri:level="1"><nlm:affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Marinskis, Germanas" sort="Marinskis, Germanas" uniqKey="Marinskis G" first="Germanas" last="Marinskis">Germanas Marinskis</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Centre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Jancoriene, Ligita" sort="Jancoriene, Ligita" uniqKey="Jancoriene L" first="Ligita" last="Jancoriene">Ligita Jancoriene</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Griskevicius, Laimonas" sort="Griskevicius, Laimonas" uniqKey="Griskevicius L" first="Laimonas" last="Griskevicius">Laimonas Griskevicius</name><affiliation wicri:level="1"><nlm:affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2021">2021</date><idno type="RBID">pubmed:33335973</idno><idno type="pmid">33335973</idno><idno type="doi">10.1016/j.ijcha.2020.100685</idno><idno type="pmc">PMC7734220</idno><idno type="wicri:Area/Main/Corpus">000646</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Corpus" wicri:corpus="PubMed">000646</idno><idno type="wicri:Area/Main/Curation">000646</idno><idno type="wicri:explorRef" wicri:stream="Main" wicri:step="Curation">000646</idno><idno type="wicri:Area/Main/Exploration">000646</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Mitigating arrhythmia risk in Hydroxychloroquine and Azithromycin treated COVID-19 patients using arrhythmia risk management plan.</title><author><name sortKey="Maneikis, Kazimieras" sort="Maneikis, Kazimieras" uniqKey="Maneikis K" first="Kazimieras" last="Maneikis">Kazimieras Maneikis</name><affiliation wicri:level="1"><nlm:affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Ringeleviciute, Ugne" sort="Ringeleviciute, Ugne" uniqKey="Ringeleviciute U" first="Ugne" last="Ringeleviciute">Ugne Ringeleviciute</name><affiliation wicri:level="1"><nlm:affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Bacevicius, Justinas" sort="Bacevicius, Justinas" uniqKey="Bacevicius J" first="Justinas" last="Bacevicius">Justinas Bacevicius</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Centre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Dieninyte Misiune, Egle" sort="Dieninyte Misiune, Egle" uniqKey="Dieninyte Misiune E" first="Egle" last="Dieninyte-Misiune">Egle Dieninyte-Misiune</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Burokaite, Emilija" sort="Burokaite, Emilija" uniqKey="Burokaite E" first="Emilija" last="Burokaite">Emilija Burokaite</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Kazbaraite, Gintare" sort="Kazbaraite, Gintare" uniqKey="Kazbaraite G" first="Gintare" last="Kazbaraite">Gintare Kazbaraite</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Monika Janusaite, Marta" sort="Monika Janusaite, Marta" uniqKey="Monika Janusaite M" first="Marta" last="Monika Janusaite">Marta Monika Janusaite</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Dapkeviciute, Austeja" sort="Dapkeviciute, Austeja" uniqKey="Dapkeviciute A" first="Austeja" last="Dapkeviciute">Austeja Dapkeviciute</name><affiliation wicri:level="1"><nlm:affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Zucenka, Andrius" sort="Zucenka, Andrius" uniqKey="Zucenka A" first="Andrius" last="Zucenka">Andrius Zucenka</name><affiliation wicri:level="1"><nlm:affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Peceliunas, Valdas" sort="Peceliunas, Valdas" uniqKey="Peceliunas V" first="Valdas" last="Peceliunas">Valdas Peceliunas</name><affiliation wicri:level="1"><nlm:affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Kryzauskaite, Lina" sort="Kryzauskaite, Lina" uniqKey="Kryzauskaite L" first="Lina" last="Kryzauskaite">Lina Kryzauskaite</name><affiliation wicri:level="1"><nlm:affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Kasiulevicius, Vytautas" sort="Kasiulevicius, Vytautas" uniqKey="Kasiulevicius V" first="Vytautas" last="Kasiulevicius">Vytautas Kasiulevicius</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Ringaitiene, Donata" sort="Ringaitiene, Donata" uniqKey="Ringaitiene D" first="Donata" last="Ringaitiene">Donata Ringaitiene</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Anesthesiology, Intensive Care and Pain Management Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Anesthesiology, Intensive Care and Pain Management Centre, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Zablockiene, Birute" sort="Zablockiene, Birute" uniqKey="Zablockiene B" first="Birute" last="Zablockiene">Birute Zablockiene</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Zvirblis, Tadas" sort="Zvirblis, Tadas" uniqKey="Zvirblis T" first="Tadas" last="Zvirblis">Tadas Zvirblis</name><affiliation wicri:level="1"><nlm:affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Marinskis, Germanas" sort="Marinskis, Germanas" uniqKey="Marinskis G" first="Germanas" last="Marinskis">Germanas Marinskis</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Centre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Centre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Jancoriene, Ligita" sort="Jancoriene, Ligita" uniqKey="Jancoriene L" first="Ligita" last="Jancoriene">Ligita Jancoriene</name><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author><author><name sortKey="Griskevicius, Laimonas" sort="Griskevicius, Laimonas" uniqKey="Griskevicius L" first="Laimonas" last="Griskevicius">Laimonas Griskevicius</name><affiliation wicri:level="1"><nlm:affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</nlm:affiliation><country xml:lang="fr">Lituanie</country><wicri:regionArea>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius</wicri:regionArea><wicri:noRegion>Vilnius</wicri:noRegion></affiliation></author></analytic><series><title level="j">International journal of cardiology. Heart & vasculature</title><idno type="ISSN">2352-9067</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><b>Aims</b></p><p>To assess cardiac safety in COVID-19 patients treated with the combination of Hydroxychloroquine and Azithromycin using arrhythmia risk management plan.</p></div><div type="abstract" xml:lang="en"><p><b>Methods and results</b></p><p>We retrospectively examined arrhythmia safety of treatment with Hydroxychloroquine and Azithromycin in the setting of pre-defined arrhythmia risk management plan. The data was analyzed using R statistical package version 4.0.0. A two-tailed p-value<0.05 was considered significant. 81 patients were included from March 23rd to May 10th 2020. The median age was 59 years, 58.0% were female. The majority of the study population (82.7%) had comorbidities, 98.8% had radiological signs of pneumonia. Fourteen patients (17.3%) experienced QTc ≥ 480 ms and 16 patients (19.8%) had an increase of QTc ≥ 60 ms. Seven patients (8.6%) had QTc prolongation of ≥ 500 ms. The treatment was discontinued in 4 patients (4.9%). None of the patients developed ventricular tachycardia. The risk factors significantly associated with QTc ≥ 500 ms were hypokalemia (p = 0.032) and use of diuretics during the treatment (p = 0.020). Three patients (3.7%) died, the cause of death was bacterial superinfection with septic shock in two patients, and disseminated intravascular coagulation with multiple organ failure in one patient. None of these deaths were associated with cardiac arrhythmias.</p></div><div type="abstract" xml:lang="en"><p><b>Conclusion</b></p><p>We recorded a low incidence of QTc prolongation ≥ 500 ms and no ventricular tachycardia events in COVID-19 patients treated with Hydroxychloroquine and Azithromycin using cardiac arrhythmia risk management plan.</p></div></front></TEI><pubmed><MedlineCitation Status="PubMed-not-MEDLINE" Owner="NLM"><PMID Version="1">33335973</PMID><DateRevised><Year>2020</Year><Month>12</Month><Day>19</Day></DateRevised><Article PubModel="Electronic-eCollection"><Journal><ISSN IssnType="Print">2352-9067</ISSN><JournalIssue CitedMedium="Print"><Volume>32</Volume><PubDate><Year>2021</Year><Month>Feb</Month></PubDate></JournalIssue><Title>International journal of cardiology. Heart & vasculature</Title><ISOAbbreviation>Int J Cardiol Heart Vasc</ISOAbbreviation></Journal><ArticleTitle>Mitigating arrhythmia risk in Hydroxychloroquine and Azithromycin treated COVID-19 patients using arrhythmia risk management plan.</ArticleTitle><Pagination><MedlinePgn>100685</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.ijcha.2020.100685</ELocationID><Abstract><AbstractText Label="Aims" NlmCategory="UNASSIGNED">To assess cardiac safety in COVID-19 patients treated with the combination of Hydroxychloroquine and Azithromycin using arrhythmia risk management plan.</AbstractText><AbstractText Label="Methods and results" NlmCategory="UNASSIGNED">We retrospectively examined arrhythmia safety of treatment with Hydroxychloroquine and Azithromycin in the setting of pre-defined arrhythmia risk management plan. The data was analyzed using R statistical package version 4.0.0. A two-tailed p-value<0.05 was considered significant. 81 patients were included from March 23rd to May 10th 2020. The median age was 59 years, 58.0% were female. The majority of the study population (82.7%) had comorbidities, 98.8% had radiological signs of pneumonia. Fourteen patients (17.3%) experienced QTc ≥ 480 ms and 16 patients (19.8%) had an increase of QTc ≥ 60 ms. Seven patients (8.6%) had QTc prolongation of ≥ 500 ms. The treatment was discontinued in 4 patients (4.9%). None of the patients developed ventricular tachycardia. The risk factors significantly associated with QTc ≥ 500 ms were hypokalemia (p = 0.032) and use of diuretics during the treatment (p = 0.020). Three patients (3.7%) died, the cause of death was bacterial superinfection with septic shock in two patients, and disseminated intravascular coagulation with multiple organ failure in one patient. None of these deaths were associated with cardiac arrhythmias.</AbstractText><AbstractText Label="Conclusion" NlmCategory="UNASSIGNED">We recorded a low incidence of QTc prolongation ≥ 500 ms and no ventricular tachycardia events in COVID-19 patients treated with Hydroxychloroquine and Azithromycin using cardiac arrhythmia risk management plan.</AbstractText><CopyrightInformation>© 2020 The Authors. Published by Elsevier B.V.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Maneikis</LastName><ForeName>Kazimieras</ForeName><Initials>K</Initials><AffiliationInfo><Affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ringeleviciute</LastName><ForeName>Ugne</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bacevicius</LastName><ForeName>Justinas</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dieninyte-Misiune</LastName><ForeName>Egle</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Burokaite</LastName><ForeName>Emilija</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kazbaraite</LastName><ForeName>Gintare</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Monika Janusaite</LastName><ForeName>Marta</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Dapkeviciute</LastName><ForeName>Austeja</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zucenka</LastName><ForeName>Andrius</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Peceliunas</LastName><ForeName>Valdas</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kryzauskaite</LastName><ForeName>Lina</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kasiulevicius</LastName><ForeName>Vytautas</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ringaitiene</LastName><ForeName>Donata</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Anesthesiology, Intensive Care and Pain Management Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zablockiene</LastName><ForeName>Birute</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Zvirblis</LastName><ForeName>Tadas</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Marinskis</LastName><ForeName>Germanas</ForeName><Initials>G</Initials><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Centre of Cardiology and Angiology, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jancoriene</LastName><ForeName>Ligita</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Center of Infectious Diseases, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Griskevicius</LastName><ForeName>Laimonas</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Hematology, Oncology and Transfusion Medicine Centre, Vilnius University Hospital Santaros Klinikos, Vilnius, Lithuania.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Institute of Clinical Medicine, Faculty of Medicine, Vilnius University, Vilnius, Lithuania.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>12</Month><Day>11</Day></ArticleDate></Article><MedlineJournalInfo><Country>Ireland</Country><MedlineTA>Int J Cardiol Heart Vasc</MedlineTA><NlmUniqueID>101649525</NlmUniqueID><ISSNLinking>2352-9067</ISSNLinking></MedlineJournalInfo><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Azithromycin</Keyword><Keyword MajorTopicYN="N">COVID-19</Keyword><Keyword MajorTopicYN="N">Hydroxychloroquine</Keyword><Keyword MajorTopicYN="N">QT interval</Keyword></KeywordList><CoiStatement>The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>08</Month><Day>09</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>11</Month><Day>03</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>11</Month><Day>23</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>12</Month><Day>18</Day><Hour>5</Hour><Minute>52</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>12</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2020</Year><Month>12</Month><Day>19</Day><Hour>6</Hour><Minute>1</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33335973</ArticleId><ArticleId IdType="doi">10.1016/j.ijcha.2020.100685</ArticleId><ArticleId IdType="pii">S2352-9067(20)30383-3</ArticleId><ArticleId IdType="pmc">PMC7734220</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>N Engl J Med. 2012 May 17;366(20):1881-90</Citation><ArticleIdList><ArticleId 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sortKey="Burokaite, Emilija" sort="Burokaite, Emilija" uniqKey="Burokaite E" first="Emilija" last="Burokaite">Emilija Burokaite</name><name sortKey="Burokaite, Emilija" sort="Burokaite, Emilija" uniqKey="Burokaite E" first="Emilija" last="Burokaite">Emilija Burokaite</name><name sortKey="Dapkeviciute, Austeja" sort="Dapkeviciute, Austeja" uniqKey="Dapkeviciute A" first="Austeja" last="Dapkeviciute">Austeja Dapkeviciute</name><name sortKey="Dapkeviciute, Austeja" sort="Dapkeviciute, Austeja" uniqKey="Dapkeviciute A" first="Austeja" last="Dapkeviciute">Austeja Dapkeviciute</name><name sortKey="Dieninyte Misiune, Egle" sort="Dieninyte Misiune, Egle" uniqKey="Dieninyte Misiune E" first="Egle" last="Dieninyte-Misiune">Egle Dieninyte-Misiune</name><name sortKey="Dieninyte Misiune, Egle" sort="Dieninyte Misiune, Egle" uniqKey="Dieninyte Misiune E" first="Egle" last="Dieninyte-Misiune">Egle Dieninyte-Misiune</name><name sortKey="Griskevicius, Laimonas" sort="Griskevicius, Laimonas" uniqKey="Griskevicius L" first="Laimonas" last="Griskevicius">Laimonas Griskevicius</name><name sortKey="Griskevicius, Laimonas" sort="Griskevicius, Laimonas" uniqKey="Griskevicius L" first="Laimonas" last="Griskevicius">Laimonas Griskevicius</name><name sortKey="Jancoriene, Ligita" sort="Jancoriene, Ligita" uniqKey="Jancoriene L" first="Ligita" last="Jancoriene">Ligita Jancoriene</name><name sortKey="Jancoriene, Ligita" sort="Jancoriene, Ligita" uniqKey="Jancoriene L" first="Ligita" last="Jancoriene">Ligita Jancoriene</name><name sortKey="Kasiulevicius, Vytautas" sort="Kasiulevicius, Vytautas" uniqKey="Kasiulevicius V" first="Vytautas" last="Kasiulevicius">Vytautas Kasiulevicius</name><name sortKey="Kazbaraite, Gintare" sort="Kazbaraite, Gintare" uniqKey="Kazbaraite G" first="Gintare" last="Kazbaraite">Gintare Kazbaraite</name><name sortKey="Kazbaraite, Gintare" sort="Kazbaraite, Gintare" uniqKey="Kazbaraite G" first="Gintare" last="Kazbaraite">Gintare Kazbaraite</name><name sortKey="Kryzauskaite, Lina" sort="Kryzauskaite, Lina" uniqKey="Kryzauskaite L" first="Lina" last="Kryzauskaite">Lina Kryzauskaite</name><name sortKey="Kryzauskaite, Lina" sort="Kryzauskaite, Lina" uniqKey="Kryzauskaite L" first="Lina" last="Kryzauskaite">Lina Kryzauskaite</name><name sortKey="Maneikis, Kazimieras" sort="Maneikis, Kazimieras" uniqKey="Maneikis K" first="Kazimieras" last="Maneikis">Kazimieras Maneikis</name><name sortKey="Marinskis, Germanas" sort="Marinskis, Germanas" uniqKey="Marinskis G" first="Germanas" last="Marinskis">Germanas Marinskis</name><name sortKey="Marinskis, Germanas" sort="Marinskis, Germanas" uniqKey="Marinskis G" first="Germanas" last="Marinskis">Germanas Marinskis</name><name sortKey="Monika Janusaite, Marta" sort="Monika Janusaite, Marta" uniqKey="Monika Janusaite M" first="Marta" last="Monika Janusaite">Marta Monika Janusaite</name><name sortKey="Monika Janusaite, Marta" sort="Monika Janusaite, Marta" uniqKey="Monika Janusaite M" first="Marta" last="Monika Janusaite">Marta Monika Janusaite</name><name sortKey="Peceliunas, Valdas" sort="Peceliunas, Valdas" uniqKey="Peceliunas V" first="Valdas" last="Peceliunas">Valdas Peceliunas</name><name sortKey="Peceliunas, Valdas" sort="Peceliunas, Valdas" uniqKey="Peceliunas V" first="Valdas" last="Peceliunas">Valdas Peceliunas</name><name sortKey="Ringaitiene, Donata" sort="Ringaitiene, Donata" uniqKey="Ringaitiene D" first="Donata" last="Ringaitiene">Donata Ringaitiene</name><name sortKey="Ringaitiene, Donata" sort="Ringaitiene, Donata" uniqKey="Ringaitiene D" first="Donata" last="Ringaitiene">Donata Ringaitiene</name><name sortKey="Ringeleviciute, Ugne" sort="Ringeleviciute, Ugne" uniqKey="Ringeleviciute U" first="Ugne" last="Ringeleviciute">Ugne Ringeleviciute</name><name sortKey="Ringeleviciute, Ugne" sort="Ringeleviciute, Ugne" uniqKey="Ringeleviciute U" first="Ugne" last="Ringeleviciute">Ugne Ringeleviciute</name><name sortKey="Zablockiene, Birute" sort="Zablockiene, Birute" uniqKey="Zablockiene B" first="Birute" last="Zablockiene">Birute Zablockiene</name><name sortKey="Zablockiene, Birute" sort="Zablockiene, Birute" uniqKey="Zablockiene B" first="Birute" last="Zablockiene">Birute Zablockiene</name><name sortKey="Zucenka, Andrius" sort="Zucenka, Andrius" uniqKey="Zucenka A" first="Andrius" last="Zucenka">Andrius Zucenka</name><name sortKey="Zucenka, Andrius" sort="Zucenka, Andrius" uniqKey="Zucenka A" first="Andrius" last="Zucenka">Andrius Zucenka</name><name sortKey="Zvirblis, Tadas" sort="Zvirblis, Tadas" uniqKey="Zvirblis T" first="Tadas" last="Zvirblis">Tadas Zvirblis</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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